Toradol injection belongs to a group of drugs called NSAIDs ( non steroidal anti-inflammatory drugs), that inhibits prostaglandin synthesis and is considered a peripherally acting analgesic. Toradol injection administered intramuscularly is indicated for the treatment of acute pain of short duration. It is rapidly and completely absorbed after intramuscular administration, and the result occurs in about 50 minutes after a single dose of 30 mg.
Toradol injection dosage and administration
Starting dose of Toradol injection will be adjusted according to severity of pain. The usual recommended dose is 30 mg. Doses of Toradol can be divided into 15-30 mg every 4-6 hours depending on pain intensity. A lower starting dose is preferable for patients weighting under 50 kg, and over 65 years, with mild pain. The product can be administered more frequently but total dose should not exceed 120 mg. When administering the product, both tablets and intramuscular, total dose should not exceed 120 mg per day. In treatment of acute intense pain, such as therapy immediately following surgery, the treatment can start with a dose of 30 mg, that can be repeated after 15-30 minutes, and followed by a dose of 15 mg after 6 hours. Opioid analgesics ( for example Morphine and Pethidine) can be used simultaneously if you want a more pronounced pain relief. Opioids may be more appropriate than Toradol injection, in the period immediately following surgery, when pain is more severe.
Toradol injection side effects
The most common side effects:
- gastrointestinal: nausea, dyspepsia, abdominal pain, diarrhea
- central nervous system: drowsiness, dizziness, headache, sweating
- metabolism nutritional: edema appearance
Pain at the injection site were reported in 2% of the cases. Toradol injection side effects reported less frequently:
- cardiovascular: vasodilation (sometimes noticed a slight decrease in blood pressure)
- central nervous system: dry mouth, nervousness, paresthesia (tingling, hallucinations, depression, excessive thirst, inability to concentrate, insomnia, dizziness)
- urogenital: either frequent urination or oliguria
- dermatologic: urticaria, pruritus
- sensory changes: abnormal taste and vision
Toradol injection precautions
- Renal effects: as in the case of other drugs that inhibits prostaglandin synthesis, have been reported increases in total non-protein nitrogen and creatinine during studies with Toradol injection. Because this drug is eliminated primarily trough kidneys, patients with severe renal failure should not have a treatment with it, only after risk assessment. If used in patients with renal dysfunction, doses will be reduced and renal function closely watched.
- Fluid retention and edema: this drug will be used with caution in patients with cardiac decompensation, hypertension and other cardiovascular diseases.
- Hematologic effects: this drug inhibit platelet aggregation and may prolong bleeding time. It doesn’t affect platelet count, prothrombin time (PT) or partial thromboplastin time (PTT). Patients with coagulation disorders or under treatment that interferes with hemostasis, should be kept under close observation when receiving treatment with Toradol injection.
- Hepatic effects: during treatment with this drug, minor changes may occur to one or more liver tests. These abnormalities may progress, may remain unchanged or may transient, depending on continued therapy. If clinical signs or symptoms of liver damage occur, discontinue treatment with this drug. Also, this drug is not recommended in combination with other NSAIDs because of the possibility of accumulation of Toradol side effects.
Pregnancy and breastfeeding
Toradol injectable is not recommended during pregnancy or to breastfeeding mothers.
Toradol injection for children
Safety and efficacy of this drug have not been established in children, therefore is not recommended for children under 16.
Since the elimination of this drug is lower in the elderly, they are more sensitive to renal effects of NSAIDs. That’s why it will be given extra attention and the drug will be used in the lowest effective dose.
You should always use Toradol injection under a close medical supervision to avoid any possible side effects that may occur.